Cytoprotective properties of carotenoids under conditions of entry of heavy metal salts into the body
Abstract
Studies were conducted to study the separate and combined effects of lycopene and β-carotene against the background of exposure of lead nitrate to apoptosis of cells of various functional specialization in the body. It has been shown that lycopene has a more pronounced cytoprotective effect compared to β-carotine, and with their combined effect, a cumulative effect is observed. Cytoprotective properties of lycopene are manifested in cell populations of different specialization (blood, bone marrow, thymus, spleen) under the conditions of exposure to lead nitrate and are expressed in reducing the level of cell death by the mechanism of apoptosis.
About the Authors
L. N. NikolaevichBelarus
A. A. Zgirovskaya
Belarus
References
1. Зигель, Х. Некоторые вопросы токсичности ионов металлов / Х. Зигель, А. Зигель. – М. : Мир, 1993. – 368 с.
2. Беклишев, И. Б. Действие ионов свинца на некоторые свойства эритроцитов / И. Б. Беклишев, И. В. Стеценко. – Алма-Ата : Бибилогр. ин-т физиологии, 1980. – С. 11–19.
3. Николаевич, Л. Н. Апоптоз: биологические и медицинские аспекты / Л. Н. Николаевич, Е. П. Демидчик // Becцi НАН Беларусi. Сер. мед. навук. – 2004. – № 2. – С. 99–110.
4. Биологические свойства каротиноидов и их применение в рационе питания сельскохозяйственных животных (обзор) / Л. Н. Николаевич [и др.] // Эпизоотология Иммунология Фармакология Санитария. – 2023. – № 1. – С. 53–59.
Review
For citations:
Nikolaevich L.N., Zgirovskaya A.A. Cytoprotective properties of carotenoids under conditions of entry of heavy metal salts into the body. Ecology and Animal World. 2024;(1):34-39. (In Russ.)