Neoplastic disease of small animals and latent tuberculosis infection
https://doi.org/10.47612/2224-1647-2022-1-20-32
Abstract
An antigens of tuberculosis mycobacteria (MTB), microgranulomas with acid-fast grains, cell wall deficient (CWD) MTB were found in tumors of small domestic animals. CWD MTB were isolated from tumor in all cases. The isolates did not differ in morphology and antigenic composition, either from each other or from isolates from human tumor cell cultures (Kasumi, Jurkat, Hela), had up to 26 common antigens with typical MTB, were resistant to antibiot- ics affecting cell wall synthesis. MTB as universal intracellular pathogen with unique filterability and «immortality» can be considered as the most likely etiological agent of oncogenesis based on the hypothesis following: DNA absorp- tion of aging and necrotic normal cells by persistent microorganisms, hybridization of their DNA with host DNA with subsequent expression of the hybrid genome turns normal cells into cancer ones.
About the Authors
A. P. Lysenko
РУП «Институт экспериментальной ветеринарии им. С.Н. Вышелесского»
Belarus
Belarus
M. V. Kuchvalski
Белорусский государственный университет
Belarus
Belarus
E. I. Yakobson
Белорусский государственный университет
Belarus
Belarus
E. L. Krasnikova
РУП «Институт экспериментальной ветеринарии им. С.Н. Вышелесского»
Belarus
Belarus
A. I. Poloz
Ветеринарная клиника «Главное Хвост»
Belarus
Belarus
N. V. Anikevich
Белорусский государственный университет
Belarus
Belarus
References
1. Манкин, З. В. Лимфогрануломатоз / З. В. Манкин. – Л. : Государственное издательство биологической и медицинской литературы, 1938. – 451 с.
2. Warthin, A. S. The Coexistence of Carcinoma and Tuberculosis of the Mammary Gland / A. S. Warthin // The American Journal of the Medical Sciences. – 1899. – Vol. 118, № 1. – P. 25–34.
3. Ewing, J. Neoplastic Diseases / J. Ewing. – Third edition. – Philadelphia and London : W. B. Saunders Co. Ltd., 1928. – 1127 p.
4. Fraenkel, E. Bemerkungen zur Aetiologie der Hodgkinschen Krankheit und der Leukaemia lymphatica / E. Fraenkel, H. Much // Münchener med. Wochеnschr. – 1910. – B. 57. – S. 685.
5. Lichtenstein, A. Pseudoleukämie und Tuberkulose / A. Lichtenstein // Virchows Archiv für pathologische Anatomie und Physiologie und für klinische Medizin. – 1910. – B. 202, № 2. – S. 222–237.
6. L’esperance, E. S. Studies in Hodgkin’s disease / E. S. L’esperance // An-nals of Surgery. – 1931. – Vol. 93, № 1. – P. 162–168.
7. Tuberculosis and malignancy / M. E. Falagas [et al.] // QJM: An International Journal of Medicine. – 2010. – Vol. 103, № 7. – P. 461–487.
8. Sternberg, C. Lymphogranulomatose und Reticuloendotheliose / C. Sternberg // Ergebnisse der Allgemeinen Pathologie und Pathologischen Anatomie des Menschen und der Tiere / eds. W. Hueck [et al.]. – Munich : J. F. Bergmann-Verlag, 1936. – S. 1–76.
9. Young, J. Description of an organism obtained from carcinomatous growths / J. Young // Edinburgh Medical Journal. – 1921. – Vol. 27, № 4. – P. 212.
10. Nuzum, J. W. The experimental production of metastasizing carcinoma in the breast of the dog and primary epithelioma in man by repeated inoculation of a micrococcus isolated from human breast can- cer / J. W. Nuzum // Surg. Gynec. a. Obst. – 1925. – № 48. – 336 p.
11. Sweany, H. C. Mutation forms of the tubercle bacillus / H. C. Sweany // JAMA. – 1926. – Vol. 87, № 15. – P. 1206–1211.
12. Cantwell, A. Four women against cancer: bacteria, cancer, and the origin of life. Four women against cancer / A. Cantwell. – Los Angeles : Aries Rising Press, 2005. – 144 p.
13. Livingston, V. Presence of consistently recurring invasive mycobacterial forms in tumor cells / V. Livingston, R. M. Allen // Microscop Soc Bull. – 1948. – Vol. 2. – P. 5–18.
14. Alexander-Jackson, E. A. Differential Triple Stain for Demonstrating and Studying Non-Acid-Fast Forms of the Tubercle Bacillus in Sputum, Issue and Body Fluids / E. A. Alexander-Jackson // Science. – 1944. – Vol. 99, № 2572. – P. 307–308.
15. Cultural properties and pathogenicity of certain microorganisms ob-tained from various proliferative and neoplastic diseases / V. Wuerthele-Caspe [et al.] // American Journal of Medical Sciences. – 1950. – Vol. 220. – P. 638–648.
16. Diller, I. C. Isolation of pleomorphic, acid-fast organisms from several strains of mice / I. C. Diller, A. J. Donnelly, M. E. Fisher // Cancer Research. – 1967. – Vol. 27, № 8. – P. 1402–1408.
17. Diller, I. C. Experiments with mammalian tumor isolates / I. C. Diller, A. J. Donnelly // Annals of the New York Academy of Sciences. – 1970. – Vol. 174, № 2. – P. 655–674.
18. Diller, I. C. Three similar strains of pleomorphic acid-fast organisms isolated from rat and mouse tissues and from human blood / I. C. Diller // The American Review of Respiratory Disease. – 1962. – Vol. 86. – P. 932–935.
19. Song, L.-Y. Detection of Mycobacterium tuberculosis in lung cancer tissue by indirect in situ nested PCR / L.-Y. Song, W.-S. Yan, T. Zhao // Academic journal of the first medical college of PLA. – 2002. – Vol. 22, № 11. – P. 992–993.
20. Detection of Mycobacterium tuberculosis L-forms infection in tissues of lung carcinoma / S. Zhang [et al.] // Chin. J. Public Health. – 2009. – № 11. – P. 36–38.
21. Clinical End-Points Associated with Mycobacterium tuberculosis and Lung Cancer: Implications into Host-Pathogen Interaction and Coevolution / Y. Tian [et al.] // BioMed Research International. – 2015. – Vol. 2015. – P. 1–9.
22. Livingston, V. Cancer: a new breakthrough / V. Livingston, V. Wuer-thele-Caspe. – Los Angeles : Nash Publishing, 1972. – 269 p.
23. Lung carcinogenesis induced by chronic tuberculosis infection: the experimental model and genetic control / A. Nalbandian [et al.] // Oncogene. – 2009. – Vol. 28, № 17. – P. 1928–1938.
24. McKay, K. A. The demonstration of a single species of an unclassified bacterium in five cases of bovine lymphosarcoma / K. A. McKay, D. H. Neil, A. H. Corner // Growth. – 1967. – Vol. 31, № 4. – P. 357–368.
25. Вирус бычьего лейкоза – вирусоподобная форма микобактерий туберкулеза? / А. П. Лысенко [и др.] // Экология и животный мир. – 2019. – № 1. – С. 15–24.
26. Further evidence for cancer as cell-wall-deficient mycobacterial disease / A. P. Lysenko [et al.] // Journal of Molecular Pathological Epidemiology. – 2016. – Vol. 1, № 1. – P. 1–12.
27. Вероятная связь миелоидного и лимфобластного лейкоза с туберкулезной инфекцией / А. П. Лысенко [и др.] // Эпизоотология Иммунобиология Фармакология Санитария. – 2020. – № 1. – С. 23–38.
28. Возможная роль туберкулезной инфекции в возникновении опухолей / А. П. Лысенко [и др.] // Экология и животный мир. – 2020. – № 1. – С. 53–69.
29. Василев, В. Н. Микобактериозы и микозы легких / В. Н. Василев. – София : Медицина и физкультура, 1971. – 381 с.
30. Выявление микобактерий туберкулеза в тканях с помощью дифференцирующей иммунопероксидазной окраски / А. П. Лысенко [и др.] // Туберкулез и болезни легких. – 2014. – № 10. – С. 55–58.
31. Феномен изменчивости микобактерий туберкулеза и его использование для обнаружения туберкулезной инфекции / А. П. Лысенко [и др.] // Туберкулез – глобальная катастрофа чело- вечества: материалы I Междунар. заочной науч.-практ. конф., 24 марта 2014 г. / Ростов н/Д. : РостГМУ, 2014. – С. 176–198.
32. Increased lung cancer risk among patients with pulmonary tuberculosis: a population cohort study / Y.-H. Yu [et al.] // Journal of Thoracic Oncology. – 2011. – Vol. 6, № 1. – P. 32–37.
33. Bir Köpekte Memede Beraber Seyreden Tüberküloz ve Malign Mikst Tümör / T. Kutlu [et al.] // Kafkas Universitesi Veteriner Fakultesi Dergisi. – 2018. – Vol. 24, № 2. – P. 315–318.
34. Дорожкова, И. Р. Скрыто протекающая туберкулезная инфекция / И. Р. Дорожкова, З. С. Земскова. – М. : Медицина, 1984. – 222 с.
35. Mattman, L. H. Cell wall deficient forms: stealth pathogens / L. H. Mattman. – 3rd ed. – Boca Raton : CRC Press, 2001. – 416 p.
36. Livingston, V. Myocobacterial Forms In Myocardial Vascular Disease / V. Livingston, E. Alexander-Jackson // Journal of the American Medical Women’s Association. – 1965. – Vol. 20. – P. 449–452.
37. CWD tuberculosis found in spongiform disease formely attributed to prions: its implication towards mad cow disease, scrapie and Alzheimer`s / A. P. Lysenko [et al.] // Journal of Molecular Pathologi- cal Epidemiology. – 2017. – Vol. 3, № 3. – P. 1–13.
38. Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: treating cancer like an infectious disease / R. Lamb [et al.] // Oncotarget. – 2015. – Vol. 6, № 7. – P. 4569–4584.
39. Микобактерии туберкулеза при термическом воздействии образуют защитные формы, проходящие через ультрафильтры и восстанавливающие жизнеспособность в виде CWD форм / А. П. Лысенко [и др.] // Эпизоотология Иммунобиология Фармакология Санитария. – 2019. – № 1. – С. 33–45.
40. Dong, Q. Cancer cells arise from bacteria / Q. Dong, X. Xing // Cancer Cell International. – 2018. – Vol. 18, № 1. – P. 205.
Review
For citations:
Lysenko A.P., Kuchvalski M.V., Yakobson E.I., Krasnikova E.L., Poloz A.I., Anikevich N.V. Neoplastic disease of small animals and latent tuberculosis infection. Ecology and Animal World. 2022;(1):20-32. (In Russ.) https://doi.org/10.47612/2224-1647-2022-1-20-32
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